. bi o - ph ] 3 0 Ja n 20 06 Role of mitochondria and network connectivity in intercellular calcium oscillations
نویسندگان
چکیده
Mitochondria are large-scale regulators of cytosolic calcium (Ca 2+) under normal cellular conditions. In this paper we model the complex behavior of mitochondrial calcium during the stimulation of a single cell by increase of agonist generated inositol 1,4,5-trisphosphate (IP3) concentration and find results that are in good agreement with recent experimental studies. We also study the influence of the cellular network connectiv-ity on intercellular calcium signaling via gap junction diffusion of second messengers. We include in our model the dependence of the junctional conductivity on the cytosolic calcium concentrations in adjacent cells. We consider three different mechanisms of calcium wave propagation through gap junctions: via Ca 2+ diffusion, IP3 diffusion, and both Ca 2+ and IP3 diffusion. Our results suggest that IP3 diffusion is the mechanism of Ca 2+ wave propagation and that Ca 2+ diffusion is the mechanism of synchronization of cytosolic Ca 2+ oscillations in adjacent cells. We also study the role of different topological configurations of cellular connectivity on these phenomena. We argue that the most important issue in modelling the intercellular calcium signaling is to account for the cellular topology of the tissue. Our results suggest that the dynamics of the tissue is defined by the topology of the connection graph of cells with each other.
منابع مشابه
. bi o - ph ] 8 S ep 2 00 5 Role of mitochondria and network connectivity in intercellular calcium oscillations
Mitochondria are large-scale regulators of cytosolic calcium (Ca 2+) under normal cellular conditions. In this paper we model the complex behavior of mitochondrial calcium during the action of inositol 1,4,5-trisphosphate (IP3) on a single cell and find results that are in good agreement with recent experimental studies. We also study the influence of the cellular network connectivity on interc...
متن کاملGABA-mediated membrane oscillations as coincidence detectors for enhancing synaptic efficacy in the developing hippocampus
Spontaneously occurring neuronal oscillations constitute a hallmark of developmental networks. They have been observed in the retina, neocortex, hippocampus, thalamus and spinal cord. In the immature hippocampus the so-called ‘giant depolarizing potentials’ (GDPs) are network-driven membrane oscillations characterized by recurrent membrane depolarization with superimposed fast action potentials...
متن کاملGABA-mediated membrane oscillations as coincidence detectors for enhancing synaptic efficacy in the developing hippocampus
Spontaneously occurring neuronal oscillations constitute a hallmark of developmental networks. They have been observed in the retina, neocortex, hippocampus, thalamus and spinal cord. In the immature hippocampus the so-called ‘giant depolarizing potentials’ (GDPs) are network-driven membrane oscillations characterized by recurrent membrane depolarization with superimposed fast action potentials...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2008